Medicinus – Cours de Médecine en ligne


(Last Updated On: 10 March 2020)


Biological actions:

At the epidermal level: DCs have an atrophying effect

At the dermal level: the strongest DCs inhibit fibroblast growth and decrease collagen and elastic fiber synthesis


Activity / Level Dci Specialty
Very strong / IV

Betamethasone dipropionate

Clobetasol propionate



Forte / IV

Betamethasone dipropionate

Hydrocortisone acponate

Hydrocortisone butyrate


Diprosone® / Betasone®




Moderate / II Desonide Locapred®
Low / I Hydrocortisone Hydracort® / Cortiderm®


DC-related factors: liposolubility and concentration, nature of excipient (penetration favoured by an ointment), presence of adjuvants (salicylic acid and urea)

Skin-related factors: altered skin (increased penetration), good hydration (better diffusion), anatomical site (depending on the thickness of the corneal layer), age (increased absorption in elderly subjects and premature), skin temperature (increased penetration with increased local heat)

Factors related to the mode of application: application surface, duration of contact, occlusion (multiplies skin absorption by 10)

How DCs are used:

Type and surface of dermatosis: avoid very strong DCs over large areas

Lesion seat: Low to moderate DC on thin skin (face)

Patient age: Low to moderate DC in children

Cream: has very broad indications

Pommade: used for dry, hyperplasic, keratosic dermatoses. Avoid in creases

Gel: useful for oozing lesions and creases

Lotion: suitable for hairregions

In case of prolonged treatment, avoid the sudden stop that exposes to the rebound effect (reappearance of symptoms), gradually reduce the power of the treatment, either by spacing the applications (1/2 then /3) or using a lower level DC


It is a symptomatic and non-etiological treatment

Anti-inflammatory indications include allergic contact dermatitis (contact eczema), atopic dermatitis, irritation contact dermatitis, photosensitization (anti-inflammatory effect on sunburn), various pruritus (except for sunburn) scabies), others (localized plane lichen, insect bites, dyshidrosis)

For antiproliferative effects: lichenification (DC suppresses pruritus and decreases infiltration), psoriasis, hypertrophic and keloid scars

Other indications: seborrheic dermatitis, plaque scleroderma, pelade, vitiligo, bubble dermatitis

With salicylic acid (Diprosalic®): for scaly dermatoses

With Daivonex® (derived from vitamin D): Daivobet®

With antifungals and antibiotics: this association is not justified


Viral, bacterial, fungal and parasitic infectious dermatoses (except for eczema scabies), ulcerated dermatosis, facial dermatosis (acne, rosacea)


Atrophy: epidermal (reversible, fine epidermis in 'cigarette paper', face' ), dermal (definitive, delayed healing, pseudo-scarring, telangiectasies, bruising purpura

Skin rosaceiform dermatitis: induced acne, worsening of rosacea or perioral dermatitis

Skin infections: worsening of infection (herpes), infection secondary to dermatosis

Oculars: glaucoma, cataract / Hormonal: hypertriheals, sebaceous hyperplasia

Miscellaneous: infant gluteal granuloma (infant siege dermatosis), hypopigmentation, contact eczema allergic to CS or excipient

Exit mobile version