Medicinus – Cours de Médecine en ligne


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I- Introduction:

Dermocorticoids (DCTCs) are steroids used locally – topical;

– class (function of diagnosis, topography and age),

– galenic,

– the rate of application (less than or equal to twice a day),

– the amount needed depending on the surface to be treated.

II- Mechanisms of action:

1- Link to receivers:

DCTCs pass through the cytoplasmic membrane by simple diffusion and bind to a specific receptor of the steroid receptor superfamily.

2- The receptor complex-DCTC passes through the nuclear membrane

3- Action on the transcript:

III- Pharmacodynamic properties:

DCTCs have 3 main activities observed in therapeutics

1- Anti-inflammatory:

2- Antimitotic – Antiprolifeferative:

3- Immunosuppressive:

IV- Pharmacokinetics:

1- Bioavailability:

a)- Nature of the excipient:

b)- Additives:

c) Occlusion:

d)- Dermatosis to be treated (skin condition):

e) Topography:

(f) Age:

2- Tank effect:

3- Tachyphylaxis:

V- Classification:

There are four levels of power. Examples of DCCCs available in Algeria:


International common name

Trade name

Class 4: Very strong

Clobétasol propionate

Betamethasone dipropionate



Class 3: Forte

Betamethasone dipropionate

Mometasone furoate

Hydrocortisone aceponate

Hydrocortisone butyrate

Diprosone® /Betasone




Class 2: Moderate



Class 1: Low


Hydracort®/ cortiderm


VI- Terms of use:

1- Choice of DCTC activity:

a)- Dermatosis to be treated:

b)- The surface to be treated and the seat:

c) Patient age:

2- Choice of the excipient:

3- Rhythm and application technique:

4- Monitoring treatment:

VII- Indications:

DCTCs are a symptomatic and non-etiological treatment.

1- For their antiinflammatory effect:

2- For their anti-proliferative effect:

3- For their immunosuppressive effect:

VIII- Intralesional injections:

IX- Corticosteroids in combination:

X- Side effects of dermocorticoids:

1- Atrophy:

2- Facial dermatitis:

3- Skin infections:

4- Eye side effects:

5- Hormonal effects:

6- Uncontrolled cause dermatoses:

7- Various:


Professor AS. CHEHAD

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